Adjuvant Disease in Rats: Biochemical Criteria for Distinguishing Several Phases of Inflammation and Arthritis

Abstract

(1) The impaired drug metabolism, associated with adjuvant arthritis, spontaneously returns towards normal after 6 weeks. (2) The plasma protein thiol titer falls precipitiously with onset of arthritis but eventually returns to normal. (3) Based on these and other criteria, at least five phases of the disease can be distinguished which are summarized in Table III. (4) The Buffalo rat may develop massive arthritis, though relatively resistant to conventional adjuvants.