Role of Cations in Conglutination and in Formation of Properdin Zymposan Complex from Bovine Serum

Abstract

The conglutination of sensitized sheep erythrocytes or zymosan requires Ca++. Mg++ and Ba++ are inactive but Sr++ appears to substitute to a limited extent for Ca++. Zymosan inhibits conglutination of sensitized sheep cells by bovine serum. Bovine properdin and zymosan react readily in the absence of Ca++, but in the presence of Mg++, without any interference due to conglutination.