Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease. - Concepedia

Concepedia

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Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease.

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References

1996

Year

Toshiaki Irie, Kiyoshi Fukushi, Hiroki Namba, Masaomi Iyo, Hiroshi Tamagami, Shin‐ichiro Nagatsuka, Nobuo Ikota

Abstract

The [14C]MP4A and [14C]MP4P esters had sufficient sensitivity to enable AchE activity changes in the rat cortex of less than 50% to be detected, indicating that the present method is applicable to PET diagnosis of Alzheimer's disease.