Intravenous Omeprazole in Children: Pharmacokinetics and Effect on 24-Hour Intragastric pH

Abstract

In critical situations, intravenous administration of omeprazole may be required in infants. The authors demonstrate that the dose of 20 mg/1.73 m2 is not effective in maintaining 24-hour gastric pH of more than 4 and that a dose of 40 mg/1.73 m2 is required.