A Potent Chemotherapeutic Agent Against Fish Diseases

Abstract

6-Hydroxymethyl-2[2-(5-nitro-2-furyl) vinyl] pyridine (P-7138) showed the inhibitory activity in vitro at low concentrations (1mcg/ml or less) against the most of the tested gram positive and negative bacteria including several strains isolated from fishes and also active in vitro against fungi and trichomonas. This agent exhibited the therapeutic effect by both oral administration and bathing in fishes infected with Aeromonas liquefaciens. Especially the effect by bathing was excellent in low concentrations. The distribution and toxicity of this agent in fishes were also investigated.