The Effect of Chronic Alcohol Administration on Enzyme Profile and Glyceride Content of Heart Muscle, Brain and Liver

Abstract

SummaryThe effect of chronic alcohol administration (10 weeks) on the glyceride content and enzyme profile of heart muscle, brain, and liver was examined in the dog. A significant increase (2.8-fold) in glyceride content of cardiac muscle was observed in the alcohol consuming animal, without concomitant changes in myocardial enzyme profile. Chronic alcohol administration resulted in a significant increase in activity of glycolytic and oxidative enzymes of the brain, but without parallel changes in the glyceride content of the brain. Ten-week long ethanol administration resulted in a 3.5-fold increase in glyceride content and a significant increase in activity of glycolytic and oxidative enzymes of the liver.