Changes in Total Peripheral Resistance in Endotoxin Shock.

Abstract

SummaryA series of experiments has been carried out on dogs to determine total peripheral resistance changes in endotoxin shock. Animals were perfused with homologous heparinized blood at controlled and measured cardiac inflows. Results suggest that the onset and course of irreversible shock are characterized by a progressive fall in total peripheral resistance. The mechanism of the decline in resistance has been suggested by earlier studies from this laboratory.