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Influence of Excess Dietary Phenylalanine on Pregnant Rats and Their Fetuses
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1964
Year
NutritionExcess PhenylalanineFetal MedicineGynecologyFetal HealthPregnant RatsMolecular NutritionMaternal NutritionPublic HealthPlacental DevelopmentExcess Dietary PhenylalanineAnimal NutritionMaternal TyrosineMaternal HealthMaternal-fetal MedicineEndocrinologyPlacental FunctionPregnancy NutritionTheir FetusesPhysiologyNutritional ScienceMetabolismMedicineFetal Tyrosine
High blood phenylalanine levels and low phenylalanine hydroxylase activity were found in pregnant female rats fed excess phenylalanine. Fetal plasma phenylalanine levels averaged twice as high as the maternal levels. Tyrosine levels were elevated in pregnant females and in their fetuses. The ratio of fetal tyrosine to maternal tyrosine was lower in phenylalanine fed pregnant rats than in normally fed pregnant rats.