Muramidasuria and Hyperkaluria in the Chloroleukemic Rat

Abstract

The transplanted rat chloroleukemia cytologically similar to human acute myelocytic leukemia is associated with markedly elevated serum and urinary muramidase levels. Current metabolic studies demonstrate excessive potassium loss in the urine and appears to be related to the degree of muramidasuria. The experimental myelogenous leukemia furnishes an excellent model for the investigation of the enzyme effect on the kidney and present studies suggest that muramidase causes a direct tubular damage.