Concepedia

Ruthenium-Catalyzed C–H Oxygenation on Aryl Weinreb Amides

Fanzhi Yang, Lutz Ackermann

Organic Letters · 2013 · 115 citations · 58 references

DOI

Concepts

Abstract

Versatile ruthenium catalysts enabled unprecedented C-H bond oxygenations of aryl Weinreb amides with ample scope under exceedingly mild reaction conditions, thereby also giving access to valuable ortho-hydroxylated aldehydes. Mechanistic studies provided strong support for a kinetically relevant C-H bond activation.

References

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