Ki-1+ Large-Cell Anaplastic Lymphoma After Ewing Sarcoma

Abstract

Purpose: A large cell anaplastic lynphoma that developed after treatment of a Ewinig sarcoma (ES) is described. Patient: An II-year-old girl with a pelvie ES developed a large cell. Ki-1+. anaplastic lymphoma in the same anatomic location 10 months alter multimodal therapy Results: ES recurred in the primarv site 16 months alter allogeneic marrow transplantation and 3.5 years alter initial diagnosis, but the patient remains m remission from her lymphoma. Conclusion: The occurrenee of lymphoma and ES in a short time interval in the same patient is very unusual. Whether etiologic factors other than chemoradiotherapy. including genetic disposition. play a role remains to he elucidated.