Chemical and Pharmaceutical Bulletin · 1989 · 15 citations · 0 references
MedicineMedicinal ChemistryPharmacologyCalcium HomeostasisNeuropharmacologyPharmacodynamicsCalcium MetabolismCalcium SignalingCalcium Transport ProteinsIntracellular Calcium SignalingCa2+ SignalingCalcium Influx MechanismsCalcium Ion SignalingCalcium Signaling Through Ion ChannelsCalcium TransportCalcium-induced Calcium ReleaseVoltage-dependent Channel ActivationVoltage-dependent Channel Behavior
Further experiments were conducted to examine the effect of scoparone (6,7-dimethoxycoumarin), a coumarin derivative found in the Chinese crude drug "Capillaris Flos," on calcium mobilization. Scoparone does not affect Ca2+ influx through the voltage-dependent channel due to membrane depolarization. Its inhibitory action may be dependent not only on the inhibition of Ca2+ release from sarcoplasmic reticulum but also on the inhibition of extracellular Ca2+ influx through the receptor-operated channel.