Publication | Open Access
From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination
125
Citations
38
References
2014
Year
Hydrogen Borrowing StrategyChemical EngineeringEngineeringIndustrial CatalysisAvailable RutheniumOrganic ChemistryRacemic AlcoholsPnp-type Pincer CatalystCatalysisStereoselective SynthesisChemistryHomogeneous CatalysisAsymmetric CatalysisEnantioselective SynthesisCatalytic Synthesis
A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman's chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.
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