Biochemical Significance of Serum Glycoproteins. III. Hepatic Production of  1 and  2 Globulins Responding to Injury.

Abstract

Seromucoid fraction of rat serum was shown by immunoelectrophoresis to contain albumin (a trace), 2 α1-globulins, including the α1 of Darcy, 3 α2 and 1 βglobulin. The changes in serum levels of the α1-globulin of Darcy and haptoglobin (an α2-globulin) were compared with the seromucoid fraction in rats 24 hours following laparotomy and partial hepatectomy. Both proteins, as well as the seromucoid fraction itself, were elevated following injury; these increases were either abolished or considerably reduced by partial hepatectomy. These observations are consistent with the concept that the liver is the major source of the α-globulins produced in response to injury.