β-Alkoxyvinyl trifluoromethyl ketones as efficient precursors for the one-pot synthesis of bis-(4,5-dihydro-1H-pyrazol-1-yl)methanones and 1H-pyrazolyl-1-carbohydrazides

Abstract

The one-pot and regioselective synthesis of a novel series of 3-aryl(heteroaryl)-5trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazolyl-1-carbohydrazides and bis-(3-aryl-5trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl)methanones from the cyclocondensation reactions of 4-alkoxy-4-aryl(heteroaryl)-1,1,1-trifluoroalk-3-en-2-ones, where aryl substituents are H, Me, Ph, 4-OMePh, 4-ClPh, 4-BrPh, 4,4'-biphenyl and heteroaryl are 2-thienyl and 2furyl, with carbohydrazide is reported.