Comparative study of X-ray treatment and photodynamic therapy by using 5-aminolevulinic acid conjugated gold nanoparticles in a melanoma cell line

Abstract

The conjugate does not cause any enhancement of radiation efficiency on MeL-Rm cell line. With regards to PDT, we found that the conjugate induced cell death at twice the rate when compared with 5ALA alone. Therefore, the conjugate can be an appropriate delivery agent for 5ALA and may also enhance the destruction of tumor cells. Finally, comparing the two types of treatment shows that PDT is a more efficient treatment for this cell line.