Synthesis of Pyrrole Derivatives from Diallylamines by One-Pot Tandem Ring-Closing Metathesis and Metal-Catalyzed Oxidative Dehydrogenation

Abstract

A series of aryl-substituted pyrrole derivatives was synthesized from diallylamines through a ruthenium carbene catalyzed ring-closing metathesis reaction and in situ oxidative dehydrogenation reaction catalyzed by FeCl3·6H2O or CuCl2·2H2O in the presence of O2. The reaction was mild, simple, and convenient. An oxygen atmosphere played a critical role in obtaining high conversion of substituted pyrroles in the proposed catalytic system.