Inhibitory Effect of Nitrogen Mustard (Bis Beta-Chloroethyl Amine) on Lesions of Experimental Serum Hypersensitiveness.

Abstract

Periodic intravenous injections of the nitrogen mustard, bis beta-chloroethyl amine, suppressed both antibody formation and the development of vascular lesions in rabbits injected intravenously with a massive dose of horse serum. The incidence of vascular lesions was directly correlated with the amount of antibody produced, since all rabbits with terminal amounts of antibody in excess of 0.06 mg nitrogen per ml exhibited vascular lesions. Cutaneous hypersensitiveness failed to develop in rabbits which did not produce detectable amounts of anitbody.