Amelioration of Ischemia-Reperfusion Injury in Rat Intestine by Pentoxifylline-Mediated Inhibition of Xanthine Oxidase

Abstract

Pentoxifylline ameliorates histopathologic signs of injury and decreases lipid peroxidation (TBARS). Normal xanthine oxidase-xanthine dehydrogenase ratios in the treated compared with IR-only animals imply that the protective effect of PTX is at least partially mediated through inhibition of xanthine oxidase.