AN EXPERIMENTAL STUDY OF ANALGESIC ACTIVITY OF SELECTIVE COX-2 INHIBITOR WITH CONVENTIONAL NSAIDs

Abstract

The present study was carried out to investigate the analgesic activity of Etoricoxib (10 mg) for individual drug therapy and etoricoxib (5 mg) for combination therapy with diclofinac potassium (10 mg) using Acetic acid induce writhing, Hot plate and Tail immersion methods. The test and standard drugs significantly (p<0.001) reduced the number of abdominal constriction and stretching of hind limb induce by the injection of acetic acid in a dose dependent manner. The Hot plate and Tail immersion test useful in the elucidating centrally mediated antinociceptive responses, which focused mainly on changes above the spinal cord level. All the test and standard drugs significantly (p<0.001) reduced the pain as compare to the control group. The results of pharmacological tests performed in the present studies suggest the combination of Etoricoxib and diclofenac potassium possess potent analgesic activity.