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Production of Diabetes Mellitus in Rats with Alloxan.
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1943
Year
Metabolic SyndromePancreatic IsletsHealth SciencesMedicinePhysiologyDiabetesTypical DiabetesDiabetes MellitusInsulin DeliveryMetabolismPharmacologyInsulin SignalingBeta Cells
A single intraperitoneal injection of 200 mg/kg of alloxan into white rats causes typical diabetes mellitus. The histologic changes are necrosis and complete disappearance of the beta cells from the pancreatic islets.