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Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid(DNA) strand breakage activity.
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1991
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Bioorganic ChemistryMolecular BiologyDeoxyribonucleic AcidDna Strand BreakageChemical BiologyPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryNucleic Acid ChemistryBreakage ActivityPyrazine DerivativesBiochemistryOligonucleotideDna ReplicationDrug DevelopmentPharmacologyNatural SciencesMedicineDrug Discovery
Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+.