The polysaccharide from Lampteromyces Japonicus.

Abstract

From Lampteromyces japonicus, a polysaccharide was extracted with hot water and purified by deproteinization, removal of nucleic acid and DEAE cellulose column chromatography. The purified neutral polysaccharide, [α]34D+218.3° (c=0.93, H2O), was white powder and constituted of mannose, glucose and galactose in the molar ratio of 1 : 0.66 : 0.54. The tumor inhibition ratio of the polysaccharide against the implanted sarcoma 180 in mice was 55.1% in the doses of 40 mg/kg/day for 5 days, and the tumors in 3 of 8 mice completely regressed.