Histamine, Norepinephrine, and Bradykinin Stimulation of Fibroblast Growth and Modification of Serotonin Response

Abstract

Histamine and norepinephrine have a concentration-dependent growth-enhancing effect on fibroblast growth in vitro that is different from the response to serotonin. These distinct dose-response curves suggest different mechanisms of action. Furthermore, histamine depresses growth of human embryo lung fibroblasts while enhancing growth of an established cell line (3T6) and serially cultured strains of mouse skin fibroblasts. The acquired nature of the histamine response is in contrast to the consistent growth-enhancing effect of serotonin and norepinephrine on all fibroblast lines or strains.