Effect of Normal Metabolites on the Oxygen-Hemoglobin Equilibrium

Abstract

SummaryA number of substances, most of them normal intermediates of red cell glucose metabolism, were tested for their effect on the shift in the oxygen dissociation curve produced by 2,3-diphosphoglycerate. None of the substances tested, with the exception of ATP and pyridoxal phosphate had any effect on the dissociation curve, either in the presence or absence of 2,3-DPG, ATP and pyridoxal phosphate caused a rightward displacement of the dissociation curve, but this occurred both in the presence and absence of 2,3-DPG and was considered to be simply an additive effect.