Rate of release of medicaments from ointment bases containing drugs in suspension.

Abstract

Higuchi's equation that expresses the rate of release of medicaments from ointments containing drugs in suspension has long been used for its surprisingly simple form and convenience. If initial drug concentration is close to the solubility of the drug in the ointment base, however, accuracy of the equation is not always high. In order to improve the accuracy, explicit solution of Fick's laws with the appropriate boundary conditions was attempted.