The isolation of a toxic substance from the blood of uremic patients

Abstract

The analyses of bloods from cases of uremia have yielded a substance which is toxic. Control analyses of bloods from a wide variety of conditions not associated with uremia failed to discover a similar substance. Guinea-pigs were used as the test animal and enough material can be recovered from 200 c.c. of uremic blood to cause death. The isolation of the substance was effected by a combination of several methods in current use for the separation of animal bases.