Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

Mechanism of phenobarbital-induced hypercholeresis in the rat

P. Berthelot, Serge Erlinger, Daniel Dhumeaux et al. · American Journal of Physiology-Legacy Content · 1970 · 212 citations

Medicine, Pharmacology, Physiology +5

Sex-dependent differences in drug metabolism in the rat. I. Temporal changes in microsomal drug-metabolizing system of the liver during sexual maturation.

Gerald M. Cohen, Gilbert J. Mannering · PubMed · 1974 · 101 citations

Medicine, Biochemistry, Pharmacology +17

Defective Bromosulfophthalein Clearance in Patients with Constitutional Hepatic Dysfunction (Gilbert's Syndrome)

Paul D. Berk, Terrence F. Blaschke, Jeanne G. Waggoner · Gastroenterology · 1972 · 94 citations

Pharmacy, Internal Medicine, Pharmacokinetics +12

The effect of phenobarbital pretreatment on the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl-1-nitrosourea (PCNU), and on the plasma pharmacokinetics and biotransformation of BCNU.

Victor A. Levin, J Stearns, Angel S. Byrd et al. · Journal of Pharmacology and Experimental Therapeutics · 1979 · 81 citations

Pharmacy, Pharmacokinetics, Pharmacology +13