In Situ Drug Release Monitoring with a Fiber-Optic System: Overcoming Matrix Interferences Using Derivative Spectrophotometry

Abstract

The use of automation has increased in all the fields of the pharmaceutical industry, such as manufacturing and quality control. In the field of in vitro dissolution testing, the fiber-optic system is often considered a promising tool because it allows in situ monitoring of the drug release without manual sampling, liquid transfer, and hence phase separation. This paper evaluates the use of fiber-optic in vitro dissolution testing and presents a technique to compensate for analytical interferences caused by excipients.