Experimental Biology and Medicine · 1969 · 12 citations · 0 references
Life SciencesNeurobiologyNeuroscienceNeurochemistryNeuropharmacologyNeurotoxicologyAmino Acid NeurochemistryGabaergic NeurochemistryGabaergic SignalingGlutamatergic NeurochemistryGlutamatergic SignalingNeurochemical PharmacologyAlcohol Effects On Gaba SignalingAmino AcidsGaba Biosynthesis
The concentration of GABA was less in the hindbrain (in both the cerebellum and brain stem) than in the cerebrum of normal rats not given alcohol (control rats). Smaller amounts of the immediate precursor of GABA, glutamate, and its metabolites, glutamine and aspartate, were also found in the hindbrain than in the cerebrum. Administration of intoxicating doses of alcohol had no effect on the concentration of GABA in the hindbrain but produced small decreases in the concentrations of glutamate and aspartate.