Highly Stereoselective Synthesis of Functionalized Pyrrolo[3,2-<i>c</i>]quinolines <i>via N</i>-Heterocyclic Carbene Catalyzed Cascade Sequence

Abstract

An N-heterocyclic carbene-catalyzed stereoselective Michael-Mannich-lactamization cascade reaction of tosyl-protected o-amino aromatic aldimines and 2-bromoenals for the construction of functionalized pyrrolo[3,2-c]quinolines with three consecutive stereocenters was achieved in good yields with excellent diastereo- and enantioselectivities.