Journal of Veterinary Medical Science · 1995 · 20 citations · 1 references
PharmacyToxicologyVeterinary ToxicologyBiochemical ToxicologyPharmaceutical ToxicologyToxicologic PathologyCytotoxicity AssessmentCytotoxicity EvaluationBody TemperatureClinical Signs DetectionHematological AnalysisHematological BiomarkersMammalian ToxicityMolecular Mass DeterminationMolecular Mass Distribution AnalysisParasitic Diarrhea
The extract from Sarcocystis cruzi cysts in bovine muscle was subcutaneously injected to mice, guinea pigs, chickens, and rabbits to detect its toxicity. Only rabbits showed reactions after administration of the extract at a dose of 25 micrograms. The main clinical signs of the rabbits were depression, reduction in body temperature and intermittent diarrhea and the hematological findings observed were elevation in WBC, RBC, PCV, TP, BUN, AST, AUT and creatinine values and reduction in glucose, K+ and pH of blood. The extract, crude toxin, was a water soluble, acid-alkali stable and thermolabile protein and estimated to be a molecular mass of 15-16 kd.
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