Inhibition of Development of Sarcoma 180 by 4-Amino-N10-Methyl Pteroylglutamic Acid.

Abstract

The compound 4-Amino-N10-methyl pteroylglutamic acid, has shown the ability to inhibit the growth of the transplantable mouse Sarcoma 180 when administered intraperitoneally in concentrations of 1.5 mg/kg each day for 7 days. At this dosage very few mice died from drug toxicity. The inhibition is most apparent when the compound is administered early in the development of the tumor.