Sensitization to Horse Serum by Means of Adjuvants

Abstract

ConclusionsWhen guinea pigs receive an injection of horse serum combined with a lanolin-like substance and killed tubercle bacilli suspended in oil, sensitization to horse serum is similar to that seen in guinea pigs injected with living tubercle bacilli and horse serum insofar as the reactions to the intracutaneous injection of horse serum lasts longer than 48 hours and may be necrotic. The duration of intense sensitization is remarkably long. Precipitin-titers are higher in guinea pigs immunized with the aid of adjuvants. Under the conditions of these experiments, the use of the lanolin-like substance seems to be essential.