Antibiotics from basidiomycetes. XXXII. Strobilurin E: A new cytostatic and antifungal (E)-.BETA.-methoxyacrylate antibiotic from Crepidotus fulvotomentosus Peck.

Abstract

Strobilurin E is a novel antibiotic of the (E)-beta-methoxyacrylate (MOA) class produced by mycelial cultures of the agaric Crepidotus fulvotomentosus. In addition to an inhibition of fungal respiration, a feature of all MOA-antibiotics, the compound exhibits very high cytostatic activities which are accompanied by reversible morphological alterations of the cells.