The synthesis and biological activity of (±)-(1α,2α,8α)-Indolizidine-1,2-diol

Abstract

The racemic indolizidine-1,2-dio1 (6) was synthesized and found to be a weak, in vitro inhibitor of acid a-D-mannosidase (Km 0.75 × 10-2) and acid a-D-glucosidase (Km 1.1 × 10-2 M).