Protamine-like Property of Compounds 48/80 and Stilbamidine and Their Action on Mast Cells.

Abstract

Compound 48/80 and btil-bamidine produce both in vivo and in vitro bursting of rat's mast cells. This phenomenon was observed with phase contrast microscopy as a rapid bubbling of the cell surface. These compounds also possess a protamine-like effect. The possible significance of these results is discussed.