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Protamine-like Property of Compounds 48/80 and Stilbamidine and Their Action on Mast Cells.
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1953
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Medicinal ChemistryAllergyBiochemistryCompound 48/80MedicineNatural SciencesMast Cell DisorderMast CellsCell SurfaceProtamine-like PropertyChemical BiologyPharmacologyCell BiologyRapid BubblingDrug DiscoveryCompounds 48/80
Compound 48/80 and btil-bamidine produce both in vivo and in vitro bursting of rat's mast cells. This phenomenon was observed with phase contrast microscopy as a rapid bubbling of the cell surface. These compounds also possess a protamine-like effect. The possible significance of these results is discussed.