Convenient Routes to Efficiently N-PEGylated Peptides

Abstract

Efficient routes to N<i>-</i>terminal PEGylated peptides are described. Alternative supports such as superparamagnetic core-shell nanoparticles as colloidal supports and end-functional poly(styrene) as homogeneous supports improve the available solid-phase supported coupling strategies preserving ease of purification. Poly(ethylene glycol) (PEG)-peptide bioconjugates are obtained in high yield despite the use of nearly stoichiometric PEGylation agents with respect to the supported peptides.