Emergence of a small colony variant of vancomycin-intermediate<i>Staphylococcus aureus</i>in a patient with septic arthritis during long-term treatment with daptomycin

Abstract

For the first time, we identified SCVs of VISA in a patient with septic arthritis during long-term treatment with daptomycin. Daptomycin-resistant SCVs of VISA were evolved in a stepwise manner and the mutation of fabF is likely responsible for the physical and ultrastructural characteristics and daptomycin resistance.