Null association between insulin-like growth factors, insulin-like growth factor-binding proteins, and prostate cancer in a prospective study.

Abstract

IGF-1[2][1] regulates normal and neoplastic growth in the prostate [(1)][2] , and higher serum IGF-1 levels [(2)][3] appear to increase prostate cancer risk in epidemiological studies. Other aspects of the IGF axis, such as IGFBP-3 [(3)][4] , inconsistently affect risk. Retrospective studies