Aortic valve replacement for severe aortic regurgitation in asymptomatic patients with normal ejection fraction and severe left ventricular dilatation

Abstract

OBJECTIVES: According to current guidelines, aortic valve surgery is a Class II indication for asymptomatic patients with severe aortic regurgitation (AR) accompanied by left ventricular (LV) ejection fraction (LVEF) ≥ 50% and left ventricular end-diastolic dimension (LVEDD) >70 mm. This study aims to assess the postoperative outcomes of asymptomatic patients with severe AR accompanied by LVEF ≥ 50% and LVEDD >70 mm after aortic valve replacement (AVR) and to identify prognostic indicators of the surgery, especially in terms of LV ejection fraction and degree of LV dilatation. METHODS: We retrospectively identified 192 consecutive asymptomatic patients with severe AR accompanied by LVEF ≥ 50% and LVEDD > 70 mm who underwent isolated AVR from January 2003 to December 2013. Postoperative outcomes and prognostic indicators were evaluated and analysed. RESULTS: Patients had a mean age of 52.4 ± 16.1 years, and 69.3% were male. The mean LVEF and the mean LVEDD were 58.6 ± 6.6% and 76.0 ± 6.9 mm, respectively. The in-hospital mortality rate was 2.1% and survival rates at 5 and 10 years were 94.5 and 86.6%, respectively. Multivariable analysis indicated that postoperative mortality was associated with age [hazard ratio (HR) 1.059, 95% confidence interval (CI): 1.010-1.125, P = 0.049], preoperative LVEF (HR 0.860 95% CI: 0.748-0.989, P = 0.035) and LVEDD (HR 1.094 95% CI: 1.008-1.188, P = 0.032). Receiver-operating characteristic analysis showed that preoperative LVEF < 55% and LVEDD ≥ 81 mm were the best cut-off values for predicting postoperative mortality. By subgroup analysis, patients with 50 ≤ LVEF < 55% had poorer 5- and 10-year survival rates of 87.4 and 74.8% compared with 97.3% and 91.7% for patients with LVEF ≥ 55% (P = 0.023). Patients with LVEDD ≥ 81 mm had poorer 5- and 10-year survival rates of 85.6 and 72.6% compared with 98.2% and 85.6% for those with LVEDD < 81 mm (P = 0.027). CONCLUSIONS: AVR can be performed with satisfactory outcomes for severe aortic regurgitation in asymptomatic patients with severe AR accompanied by LVEF ≥ 50% and LVEDD > 70 mm. It is observed that 50% ≤ LVEF < 55% or LVEDD ≥ 81 mm are associated with poorer prognosis in patients undergoing AVR.