American Journal of Tropical Medicine and Hygiene · 1988 · 27 citations · 0 references
MedicinePharmacologyPharmacotherapyAntimicrobial PharmacologyChemotherapyInfectious Disease PharmacotherapyAntiparasitic AgentsAntiparasitic PharmacologyAntiparasitic TherapyProtozoal InfectionsProtozoan Host-parasite InteractionsProtozoan PathogenesisAntileishmanial ChemotherapyAntileishmanial TreatmentAntimalarial ChemotherapyLeishmaniasis PathogenesisMacrophage Responses To LeishmaniaPurine AnalogsPurine AnaloguesTreatment Of Leishmaniasis
Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect. We report here on strong synergistic activity between pyrazolopyrimidines and pentavalent antimonials in a human macrophage tissue culture system infected with Leishmania donovani and L. braziliensis.