Concepedia

DEHP induces obesity and hypothyroidism through both central and peripheral pathways in C3H/He mice

Ziquan Lv, Jinquan Cheng, Suli Huang, Yanwei Zhang, Shuang Wu, Yangshen Qiu, Yijie Geng, Qian Zhang, Guanqin Huang, Quan Ma,

Obesity · 2015 · 74 citations · 24 references

DOIFull text

Open access

Abstract

Chronic DEHP exposure could induce obesity by interrupting energy homeostasis, which is probably due to the synergistic effects of hypothyroidism and hypothalamic leptin resistance.

References

24

National, regional, and global trends in adult overweight and obesity prevalences

Gretchen A Stevens, Gitanjali M Singh, Yuan Lu et al. · Population Health Metrics · 2012 · 925 citations · Full text

Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males

Richard W. Stahlhut, Edwin van Wijngaarden, Timothy Dye et al. · Environmental Health Perspectives · 2007 · 638 citations · Full text

Activation of PPAR  and PPAR  by Environmental Phthalate Monoesters

C. H. Hurst, David J. Waxman · Toxicological Sciences · 2003 · 495 citations

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Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP

Hermann M. Bolt, J�rgen Angerer, Holger M. Koch · Archives of Toxicology · 2004 · 388 citations

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Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

Mark Harris, Carl Aschkenasi, Carol F. Elias et al. · Journal of Clinical Investigation · 2001 · 339 citations · Full text

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