Synthesis, Characterization, and Anticancer Effect of Trifluoromethylated Aurone Derivatives

Abstract

A series of trifluoromethylated aurone derivatives were synthesized, and the structure of 6‐hydroxy‐4‐trifluoromethylated aurone was determined by single crystal X‐ray analysis. Their anticancer activities against leucocythemia (HL‐60) and colorectal adenocarcinoma (HT‐29) were evaluated by the standard MTT method in vitro with 5‐fluorouracil as a positive contrast drug. The results showed that all the ( Z )‐trifluoromethylated aurone derivatives had potential anticancer activities.