The p.Gly61Glu Mutation in <b><i>CYP1B1</i></b> Affects the Extracellular Matrix in Glaucoma Patients

Abstract

The p.Gly61Glu mutation in CYP1B1 affects the ECM structure. This implies that the ECM of the trabecular meshwork may also be disrupted in a manner that affects aqueous humor flow resulting in increased intraocular pressure and contributing to the glaucoma phenotype.