Drug Discoveries & Therapeutics · 2016 · 22 citations · 8 references
Life SciencesEntomologyPharmacologyInsect PathologyMedical MicrobiologyMycologyAnthelmintic PharmacologyAntifungal AgentsAntifungal PharmacologyAntifungal TherapyFungal Diseases Of InsectsAntifungal TreatmentsCandida Albicans InfectionFungal Infection TreatmentNew Antifungal AgentsNovel Antifungal Drug Development
The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited no efficacy in this assay system. These results strongly suggest that trichodermin and epiisororidin E are the lead compounds for developing a new antifungal agent.
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Trichodermin, a New Sesquiterpene Antibiotic.
W. O. Godtfredsen, S. Vangedal, Kjell Undheim et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1965 · 126 citations · Full text