Human deaths induced by dog bites, United States, 1974-75.

Abstract

Introduction & Objectives: A non-targeted 12-core systematic biopsy (SBx) procedure guided by transrectal ultrasound (TRUS) is currently guideline-recommended for prostate cancer (PCa) diagnosis. Despite the risk of complications, underdiagnosis, and overtreatment associated with SBx, until now image-based targeted biopsy has not proven sufficiently accurate to replace SBx. Three-dimensional (3D) dynamic contrastenhanced ultrasound (DCE-US) was recently introduced for prostate imaging, permitting to image the entire gland with a single bolus injection. Quantitative two-dimensional DCE-US has already shown promising for PCa localization. Here, we present a new method for PCa localization by multiparametric analysis of 3D DCE-US.