Copper‐Catalyzed Regioselective Sulfenylation of Indoles with Arylsulfonyl Chlorides

Abstract

Abstract A copper‐catalyzed regioselective sulfenylation of indoles and a pyrrolo[2,3‐ b ]pyridine with arylsulfonyl chlorides has been developed by using low loadings of a copper catalyst and the cheap reductant PPh 3 . This method is effective for both N ‐protected and unprotected indoles, providing a series of structurally diverse indole thioethers in good to excellent yields with extremely high regioselectivity.