Quarterly Journal of Studies on Alcohol · 1972 · 16 citations · 0 references
PharmacyPharmacologyToxicologyAlcohol ToxicologyDrug MetabolismMetabolismAlcohol MetabolismAlcohol PharmacologyBlood Alcohol ConcentrationHepatic MetabolismAlcohol Dehydrogenase InhibitionAlcohol Elimination RateAlcohol MetabolitesBlood Alcohol EliminationBlood Alcohol PharmacokineticsHepatic Alcohol MetabolismHepatic OxidationMicrosomal Ethanol-oxidizing System
The rate of blood alcohol disappearance was unaltered by the administration of agents that either enhance (phenobarbital, benzopyrene) or inhibit (aminotriazole) the microsomal ethanol oxidizing system even when the principal enzyme for ethanol oxidation, alcohol dehydrogenase, was inhibited by pyrazole. Microsomal ethanol oxidation thus appears to have little quantitative importance in ethanol metabolism in vivo.