Increased response to prostaglandin H2 precedes changes in PGH synthase-1 expression in the SHR aorta.

Abstract

In the aorta of 20-wk-old SHR, endothelium-dependent contractions to acetylcholine are observed only when the production of nitric oxide is prevented. They are associated with an augmented sensitivity of the smooth muscle to PGH2, but not with an increased expression of PGH synthase-1.